THURSDAY, APRIL 11, 2024

12:00 PM

WELCOME REMARKS

 

Luigi D. Notarangelo, MD, President HKS

   
 

THYMIC COMPOSITION AND LYMPHOSTROMAL CROSS-TALK

12:05 PM

Mark S. Anderson, MD, PhD

 

University of California San Francisco, San Francisco, United States

 

Thymic tolerance and type 1 diabetes

12:35 PM

Diane Mathis, PhD

 

Harvard Medical School, Boston, United States

 

Thymic mimetic cells

1:05 PM

Nuno Alves, PhD

 

University of Porto, Porto, Portugal

 

Role of mesenchymal cells in thymus biology

1:35 PM

Tom Taghon, PhD

 

Ghent University, Ghent, Belgium

 

Role of thymic dendritic cells in promoting human T cell lineage specification

   

2:05 PM

Coffee Break

   

2:35 PM

Ellen V. Rothenberg, PhD

 

California Institute of Technology, Pasadena, United States

 

Gene regulatory networks in T cell commitment

3:05 PM

Thomas Boehm, PhD

 

Max Planck Institute, Freiburg, Germany

 

Molecular signals controlling intrathymic T cell development

3:35 PM

Alexander Rudensky, PhD

 

Memorial Sloan Kettering Cancer Center & Howard Hughes Medical Institute, New York, United States

 

Regulatory T cell differentiation in the thymus and beyond

4:35 PM

Coffee Break

   

5:00 PM

Graham Anderson, PhD

 

University of Birmingham, Birmingham, United Kingdom

 

Role of eosinophils in thymus regeneration

5:30 PM

Stephen Daley, PhD

 

Monash University, Victoria, Australia

 

TCR-peptide-MHC interactions redirect T cell fate in the thymus

5:30 PM

Michael Waterfield, MD, PhD

 

University of California San Francisco, San Francisco, United States

 

Role of IKAROS in mTEC development and function

6:30 PM

Ellen A. Robey, PhD

 

University of California at Berkeley, Berkeley, United States

 

T cell development in neonatal and adult thymus

   

7:00 PM

Cocktail Hour (additional charge)

   
   

FRIDAY, APRIL 12, 2024

8:30 AM

T-CELL TRAFFICKING AND IN VIVO DYNAMICS OF T-CELL RESPONSES

8:30 AM

Juan Carlos Zúñiga-Pflücker, PhD

 

Sunnybrook Research Institute, Toronto, Canada

 

Fixing to find a home for progenitor T cells

9:00 AM

Leonard I. Zon, MD

 

Harvard Medical School, Boston, United States

 

Tracking T cell development and homing in zebrafish: From the thymus to cancer niche

9:30 AM

Mark M. Davis, PhD

 

Stanford University School of Medicine & Howard Hughes Medical Institute, Stanford, United Kingdom

 

Tracking T-cell receptor specificity during immune response to infections and cancer

   

10:00 AM

Coffee Break

   

10:30 AM

THYMIC SPATIAL ORGANIZATION AND DISEASE MODELING

10:30 AM

Marita Bosticardo, PhD

 

National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States

 

In vitro modeling of hematopoietic and thymic causes of T-cell lymphopenia

11:00 AM

Ronald N. Germain, MD, PhD

 

National Institute of Allergy and Infectious Diseases, Bethesda, United States

 

High-resolution spatial organization

11:30 AM

Audrey Parent, PhD

 

University of California San Francisco, San Francisco, United States

 

Modeling human autoimmune diabetes using pluripotent stem cells

12:00 PM

Peter Zandstra, PhD

 

University of British Columbia, Vancouver, Canada

11:00 AM

Thymic organoids

 

12:30 PM

Lunch

   

1:30 PM

HUMAN CONGENITAL THYMIC AND T-CELL DEFECTS

1:30 PM

Alexandra Y. Kreins, MD, PhD

 

University College London, London, United Kingdom

 

Human congenital athymia

2:00 PM

Nicolai S.C. van Oers, PhD

 

The University of Texas Southwestern Medical Center, Dallas, United States

 

Molecular insights from congenital thymic defects in humans

2:30 PM

Sarah S. Dinges, MD

 

Charité – Berlin University of Medicine, Berlin, Germany

 

A novel defect of human thymic development

   

3:00 PM

Coffee Break

   
 

KEYNOTE

3:30 PM

Christopher C. Goodnow, PhD

 

Garvan Institute of Medical Research, Darlinghurst, Australia

 

Autoimmunity, immune tolerance checkpoints, and somatic mutations

   

4:45 PM

Vivien Béziat, PhD

 

INSERM, Paris Cité University, Paris, France

 

Human PTCRA defect reveals an unconventional route to T-cell development

5:15 PM

Tom Le Voyer, MD, PhD

 

Necker Hospital for Sick Children, Paris, France

 

NFKB2 signaling in the thymus controls production of anti-type I IFN antibodies

5: 45 PM

Gay M. Crooks, MD

 

University of California Los Angeles, Los Angeles, United States

 

In vitro generation of therapeutic T cells

   

6:30 PM

Dinner Reception (additional charge)

   

SATURDAY, APRIL 13, 2024

 

THYMOCYTE AND THYMIC EPITHELIAL CELL DEVELOPMENT

8:30 AM

Daniel Gray, PhD

 

The Walter and Eliza Hall Institute, The University of Melbourne, Melbourne, Australia

 

Age-related epithelial defects limit thymic function and regeneration

9:00 AM

Rémy Bosselut, MD, PhD

 

National Cancer Institute, NIH, Bethesda, United States

 

Single-cell and tissue transcriptomics to map intrathymic T cell developmental trajectories and lineage decisions

9:00 AM

CURRENT AND FUTURE APPROACHES TO TREATMENT

9:30 AM

John W. Sleasman, MD

 

Duke University, Durham, United States

 

Thymus implantation in the treatment of congenital athymia

10:00 AM

Marina Cavazzana, MD, PhD

 

Necker Hospital for Sick Children, Paris, France

 

Improving T cell reconstitution with pro-T cells

10:30 AM

Michail Lionakis, MD, ScD

 

National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States

 

Novel approaches to the treatment of APECED

11:00 AM

Anna Villa, MD

 

San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy

 

Gene editing-based correction of SCID

11:30 AM

CLOSING REMARKS

 

Luigi D. Notarangelo, MD, President HKS