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The Henry Kunkel Society
9650 Rockville Pike Room 6200
Bethesda MD 20814-3998
Fax: 301-634-7455
email address: info@henrykunkelsociety.org
Mary K. Crow, M.D. President
email crowm@hss.edu
phone 212-606-1397

Immunofluorescent image of antibodies to Sm
Antibodies to Sm reacting with splicesomes (snurp particles) in the nucleus in a "speckled" pattern. These particles are the sites of precursor mRNA splicing. The snurp particles are distributed in the nucleoplasm but not in the nucleoli. A cell in mitosis does not show assembly of Sm antigen into particles but Sm antigen is more diffusely distributed in the nucleoplasm outside the mitotic plate region.