To foster the development of clinical investigators focused on hypothesis-driven, patient-oriented research, particularly in the field of immunology and related subjects, as exemplified by the scientific life of Henry G. Kunkel.
As an extension of this mission, an annual meeting will be held to highlight the presentation of recent research and promote discussion on related significant scientific questions.
Henry G. Kunkel was a physician whose illustrious scientific life was distinguished by the ability to delineate principles of fundamental human biology through the meticulous study of patients with a variety of disorders of the immune system. His ability to bring a patient into the laboratory resulted in fundamental insights into the nature of the immune system and the group of diseases involving autoimmunity, immune deficiency, and malignant proliferation of the elements of the immune system. His laboratory's analyses of monoclonal proliferations delineated the polyclonal repertoire of B cells, the immunoglobulin subclasses and light chain types, the order of their genes in the human genome, and the existence of variable and constant regions of immunoglobulins.
Henry Kunkel's recognition of the antibody nature and specificity of rheumatoid factors and anti-nuclear factors was fundamental to defining the inherent autoimmune character of diseases such as rheumatoid arthritis and systemic lupus erythematosus that previously had been considered disorders of collagen and the identification of the role of immune complex formation in their pathogenesis. Work in his laboratory pioneered the identification of a variety of molecules expressed on the surface of lymphocytes including Fc receptors and MHC class II molecules.
The Kunkel laboratory was distinguished by its primary focus on the training of investigators in disease-oriented research who could think incisively about disease processes. His trainees were imparted with Henry's approach to science that was characterized by intellectual excitement, rigorous scientific rectitude, and the ability to delve deeply into the meaning and significance of an observation.
Save the Date!
The Henry Kunkel Society’s 21st Annual Meeting, “Infectious Disease Susceptibility and the Expanding Universe of Primary Immunodeficiency” will be held at Rockefeller University in New York on April 17-20, 2013.
Entitled "Autoimmunity, Inflammation and Lymphoproliferative Diseases", this 4th International Meeting will kick off with John Atkinson from Washington University, St. Louis, MO, USA as the Henry G. Kunkel Lecturer.
Make sure to save the date and look for more information to follow (including submissions of abstracts). We look forward to seeing you in Italy!
- Mike Cancro, University of Pennsylvania
- Mike Carroll, Harvard
- JL Casanova, University of Paris
- Andrea Cerutti, Weill Medical College
- Nicholas Chiorazzi, Feinstein Institute for Biomedical Research
- Carlo Croce, Ohio State University
- R Dalla-Favera, Columbia University
- Anne Davidson, Feinstein Institute for Biomedical Research
- Jean-Michael Dayer, Geneva School of Medicine
- J R Downing, St Judes Children's Hospital
- Jonathan Edwards, University College
- Sara Gaffen, University of Buffalo
- Laurie Glimcher, Harvard
- Peter Gregerson, North Shore
- John Harley, MD, PhD, Oklahoma Medical Research Foundation
- Tomas Hunig, University of Wuerzberg
- Vijay Kuchroo, MD, PhD, Brigham and Women's
- M Lecuit, Necker-Engants Malade Hospital, Paris
- Inaki Sanz, University of Rochester
- Georg Schett, University of Erlangen
- Laurence Steinmann, MD, Stanford University
- Argyrios Theofilopoulos, Scripps
- Jurg Tschopp, University of Lausanne
- P Wilson, Oklahoma Medical Research Foundation
Ouchterlony plate demonstrating different types of antinuclear
antibodies Ouchterlony double immunodiffusion where 6 SLE sera were tested against a soluble extract of calf thymus nuclear extract ie. containing multiple nuclear antigens, in the upper central well and against soluble double strand DNA in the lower central well. Sera in wells 3 and 4 have antibodies to DNA. Sera in wells 1, 2, 5 and 6 did not have antibodies to DNA but had antibodies to the Sm antigen